Incidence and clinical profile of extra-medial-temporal epilepsy with hippocampal atrophy.
نویسندگان
چکیده
We tried to investigate the incidence and the clinical profile of intractable epilepsy with hippocampal atrophy and ictal onset zones located in areas other than the hippocampus (extra-medial-temporal epilepsy; EMTE). We included patients who had hippocampal atrophy confirmed by MRI but with extra-medial-temporal ictal onset zones as verified by invasive intracranial electrodes or video-EEG monitoring. The case histories, interictal EEG, ictal semiology, other MRI findings in addition to hippocampal atrophy, and results of ictal SPECT and PET scans were evaluated. Results were compared with those of surgically proven medial temporal lobe epilepsy with hippocampal atrophy recruited during the same period. 8.5% of the intractable epilepsy patients with hippocampal atrophy had extra-medial temporal epileptogenic zones. A history of encephalitis and hemiconvulsion-hemiparesis were significantly common in the EMTE group. Most of the interictal EEGs of EMTE patients showed extratemporal irritative zones. MRI, ictal SPECT, and FDG-PET seemed to be helpful at localizing the true epileptogenic zones. The predominant EMTE seizure type was focal motor seizure with secondary generalization. Some portion of intractable epilepsy patients with hippocampal atrophy had extra-medial-temporal epileptogenic foci and careful analysis of semiology and neuroimagings could yield clues to correct diagnosis.
منابع مشابه
Comparison of temporal lobe epilepsy with hippocampal sclerosis and temporal lobe epilepsies due to other etiologies
Background: This study compares the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) with those who have temporal lobe epilepsy (TLE) due to other etiologies. Methods : In this retrospective study all patients with a clinical diagnosis of TLE were recruited in a referral outpatient epilepsy clinic at Shiraz University of Medical Sc...
متن کاملConsequences of hippocampal damage across the autobiographical memory network in left temporal lobe epilepsy.
Lesion and neuroimaging evidence suggests the hippocampus (HC) is a crucial node in the neural network supporting autobiographical memory (AM) retrieval, and thus focal damage to the HC may have functional consequences for structures throughout the network. Using fMRI, we examined the impact of hippocampal damage on the engagement and connectivity of the AM network in 11 patients with left temp...
متن کاملAnterior temporal changes on MR images of children with hippocampal sclerosis: an effect of seizures on the immature brain?
BACKGROUND AND PURPOSE Ipsilateral loss of anterior temporal gray-white matter definition, due mainly to white matter signal intensity abnormality, is frequently seen on MR images of patients with hippocampal sclerosis. Our aim was to determine the prevalence and clinical correlations of these anterior temporal changes in pediatric cases of hippocampal sclerosis and to determine whether cumulat...
متن کاملImaging findings in hippocampal sclerosis: correlation with pathology.
We evaluated the ability of preoperative radiologic imaging to detect hippocampal sclerosis in 31 patients who underwent surgery for intractable epilepsy. Hippocampal sclerosis is commonly associated with surgically treatable temporal lobe epilepsy. It is pathologically described as neuronal cell loss with associated gliosis in the hippocampus. While previous reports have correlated imaging res...
متن کاملHippocampal atrophy on MRI in frontotemporal lobar degeneration
Background: Hippocampal atrophy on MRI is an early characteristic of Alzheimer’s disease (AD). However, hippocampal atrophy may also occur in other dementias, like frontotemporal lobar degeneration (FTLD). Aim: To investigate hippocampal atrophy on MRI in FTLD and its three clinical subtypes, in comparison to AD, using volumetry and a visual rating scale. Methods: Forty-two patients with FTLD (...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of Korean Medical Science
دوره 16 شماره
صفحات -
تاریخ انتشار 2001